TYPE I IFN SIGNATURE IN CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A CONSPIRACY OF DNA- AND RNA-SENSING RECEPTORS?

Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

Abstract Background Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-systemic autoimmune disease.Interferon type I (IFN-I) plays a pivotal role Iodine Supplements in the pathogenesis of SLE.The objective of this study was to assess the prevalence of the IFN-I signature and the contribution of cytosolic nucleic acid receptor

read more

Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1

Abstract Imatinib (IM), targeting of BCR-ABL1 tyrosine kinase, is currently one of the first-line choices in the treatment of chronic myeloid leukemia (CML).This study aims to explore the molecular mechanisms underlying IM resistance in CML treatment.108 CML patients were recruited and grouped according to their sensitivity to IM as the responder g

read more


Global Movement to Promote Human Security for All

Humanity confronts complex, multidimensional challenges to the security of the people and the planet we live on.These threats continue to defy resolution by means of the existing policies, institutions and actions of nations around the world.In spite of unprecedented and Ozautosport remarkable achievements, our sense of insecurity continues to rise

read more